Fat Joe released his sixth album All or Nothing, noted for featuring the popular diss track "My Fofo", aimed at fellow New York rapper 50 Cent, who had dissed Joe for recording with Ja Rule. All or Nothing spawned the singles "So Much More" and "Get It Poppin" featuring Nelly, also with guest appearances from Eminem, Mase, Remy Ma, Mashonda, and R. Kelly. Responding to "My Fofo", 50 Cent attacked Fat Joe in his song "Piggy Bank" from his 2005 album The Massacre. Fat Joe subsequently attacked 50's street credibility and called him a "coward" on a phone interview with Kay Slay of New York City hip-hop radio station WQHT.The conflict carried on at the 2005 MTV Video Music Awards, while Fat Joe introduced the reggaeton act featuring Daddy Yankee, Joe remarked, "I feel safe with all the police protection—courtesy of G-Unit.Shortly after, when MTV switched to a commercial break, 50 Cent directed an obscenity at Joe, and 50 Cent jumped on stage as Fat Joe was leaving.
The 50 Cent feud continued, and more.
Verbal disputes between Fat Joe and 50 Cent continued.In September 2007, on the BET program Rap City, 50 Cent accused Fat Joe of being cowardly for not willing to confront him, but Fat Joe dismissed this claim as nonsense.Later in January, 50 Cent released another Fat Joe diss, called "Southside ***** (I'm Leaving)". At the end of January 2008, Fat Joe and his longtime accountant Brian Dittrich both denied rumors spreading on the Internet that Fat Joe owed the IRS in taxes.
On March 20, 2008, shortly after record sales were released for Fat Joe's new album The Elephant in the Room, 50 Cent released a video via online, which features the "funeral" of Fat Joe, which shows 50 Cent crying in the fake footage. 50 Cent then talks about Fat Joe's record sales, and states that he ended Fat Joe's career (like he says he did to Ja Rule's) and that his mixtape blew out Fat Joe's album.